Another thing that people don't realize about desires and fulfillment
I'll keep this short and sweet. What people don't realize is that it isn't about what you do and what you have, it's about how those things in your life make you feel. What feelings actually contribute significantly to your overall sense of fulfillment in life? What experiences provide you with those feelings?
Your life could look amazing. You could have what certain societies and cultures praise - things that many people genuinely want. However, if you don't have what you genuinely want on a profound level - if you don't have what makes you feel fulfilled in life - then the emptiness will remain. Things may distract you from it. You might be able to lie to yourself to an extent. However, at the end of the day, you'll realize that you feel like something is missing in your life and whatever you have isn't enough.